DermaFlux™ Cream Base
Designed for Modern Pharmaceutical Compounding

A smooth, hypoallergenic, paraben-free cream base optimised for transdermal and topical delivery of active pharmaceutical ingredients—developed specifically for compounding pharmacies.

Optimised for topical and transdermal pain formulations

Smooth, non-sticky, odourless and highly moisturising

pH suitable for multi-API pain and anti-inflammatory creams

Hypoallergenic, paraben-free, MI/MCI-free, mineral oil–free, petrolatum-free

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What is DermaFlux™?

DermaFlux™ is a next-generation oil-in-water cream base developed exclusively for professional compounding pharmacies. It is engineered to provide a cosmetically elegant, smooth, non-sticky vehicle that supports the delivery of a wide range of active pharmaceutical ingredients (APIs), particularly in topical pain and inflammation formulations.

With its pH-stable, hypoallergenic and odourless profile—and a formulation that is paraben-free, MI/MCI-free, mineral oil–free, and petrolatum-free—DermaFlux™ offers both formulation flexibility for pharmacists and high patient acceptability for long-term use.

For professional compounding use only. Not a finished drug product.

Why Dermaflux™?

A versatile base with patient-friendly elegance

Smooth, Non-Sticky Texture
Glides easily, spreads evenly, and dries without a tacky or greasy feel—supporting patient adherence, especially in chronic pain management.

Hypoallergenic & “Free-From” Formulation Designed to be hypoallergenic and free from parabens, MI/MCI, mineral oil, and petrolatum, helping to minimise the risk of irritation or sensitisation in patients, including those with more sensitive skin.

pH Suitable for Topical Pain Creams Developed within a pH range suitable for many common analgesic, anti-inflammatory, and neuropathic APIs, balancing tolerability with stability.

Cosmetically Elegant & Odourless White, smooth, glossy, and odourless—patients can use it comfortably under clothing, at work, and during daily activities.

Versatile Across Therapeutic Categories Suitable for formulations in MSK pain, sports medicine, dermatology, and localised treatments requiring a clean, elegant vehicle.

Built for Dermal & Transdermal Performance

A modern oil-in-water system supporting API delivery

DermaFlux™ is based on a modern oil-in-water emulsion system designed to support both drug release from the vehicle and penetration into the skin where clinically appropriate.

Suitable for hydrophilic – lipophilic APIs

The base maintains a stable, uniform dispersion of APIs, helping to support consistent dosing across the applied area.

Its hydrating yet non-occlusive character helps soften the stratum corneum without leaving an overly occlusive or greasy film, a balance that can favour penetration while maintaining patient comfort.

Designed with a pH range appropriate for many pain and anti-inflammatory APIs, helping support both chemical stability and skin tolerability.

Compounding pharmacists should always confirm API-specific solubility, stability, and beyond-use dating in accordance with professional guidelines.

One base, multiple therapeutic possibilities

Clinical Application Areas

Musculoskeletal & Arthritis Pain

Ideal for multi-API formulations targeting inflammatory, nociceptive, and neuropathic components of pain.

    • Chronic osteoarthritis
    • Low back pain
    • Localised joint and soft-tissue pain

Sports Medicine & Rehabilitation

Suitable for athletes and active patients who require non-sticky, quick-absorbing topical preparations.

    • Acute injuries
    • Overuse syndromes
    • Post-rehabilitation support

Dermatologic & Localised Therapies

When a non-greasy, odourless, hypoallergenic cream is preferred over heavier ointments, without compromising on elegance or comfort.

Sensitive or High-Use Areas

Areas where patients apply cream multiple times daily, or under clothing, benefit from a light, clean-feeling, free-from base.

Designed for Compounding Pharmacists

Workflow efficiency meets formulation flexibility

  • Ready-to-use cream base reduces preparation time once the formula is defined.
  • Compatible with standard compounding equipment (ointment mills, EMPs, geometric dilution).
  • Supports standardisation of clinic protocols—same base, different strengths or combinations of APIs.
  • Helps improve consistency between batches and simplify staff training.

Formulation Guidance (High-Level)

DermaFlux™ can be used as a vehicle for both:

  • Dissolved APIs – where solubility or co-solvents permit, and
  • Dispersed APIs – where powders are appropriately micronized and uniformly incorporated.

Key considerations:

  • Confirm API solubility and compatibility with the base and any co-solvents.
  • Verify target concentration and dose per unit area of skin.
  • Assign beyond-use dating in line with relevant guidelines, water activity, and available stability data.
  • Choose appropriate packaging—e.g., airless pumps, tubes, jars—based on product viscosity and patient use.

Specific formulation and stability should be evaluated by the compounding pharmacist for each API and combination.

Frequently Asked Questions

Is DermaFlux™ hypoallergenic?

Yes. DermaFlux™ is formulated to be hypoallergenic, with a focus on minimising excipients commonly associated with irritation or sensitisation.

Is DermaFlux™ free from parabens and MI/MCI?

Yes. DermaFlux™ is paraben-free and MI/MCI (methylisothiazolinone / methylchloroisothiazolinone)–free, aligning with modern expectations for “cleaner” base formulations, especially in chronic-use pain creams.

Does DermaFlux™ contain mineral oil or petrolatum?

No. DermaFlux™ is mineral oil–free and petrolatum-free, providing a light, non-occlusive feel while still maintaining moisturising properties.

Is DermaFlux™ suitable for multi-API pain formulations?

DermaFlux™ is designed with a pH range and emulsion system suitable for many commonly compounded analgesic, anti-inflammatory, and neuropathic APIs. Pharmacists should verify compatibility, solubility, and stability for each specific formulation.

Is DermaFlux™ a finished drug product?

No. DermaFlux™ is a cream base only, intended for use by licensed compounding pharmacies and healthcare professionals. It must be combined with APIs according to a prescriber’s directions and applicable regulations.

What types of patients benefit most from DermaFlux™-based formulations?

DermaFlux™ is particularly well suited for patients requiring chronic or frequent application (e.g., osteoarthritis, chronic MSK pain, sports injuries), and for those who prefer non-greasy, hypoallergenic, odourless topical preparations.

Bright Horizon Group Inc.
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